If you have a proposal or Director nomination that you would like included in our Proxy Statement and form of proxy for, or to be presented at the 2009 Annual Meeting of Stockholders, you must send the proposal to Isis by no later than December 22, 2008. Stockholders wishing to submit proposals or Director nominations that are not to be included in such Proxy Statement and proxy must do so no earlier than the close of business on February 5, 2009 and no later than the close of business on March 7, 2009. Stockholders are also advised to review our Bylaws, which contain additional requirements with respect to advance notice of stockholder proposals and Director nominations.

2008 ANNUAL MEETING

On June 5, 2008, we held our Annual Meeting of Stockholders in Carlsbad, California for the following purposes:

1. elect three Directors each to serve for a three-year term;
2. approve an Amendment to the 2002 Non-Employee Directors’ Stock Option Plan to increase the annual non-discretionary stock option grant for our non-employee Directors from 12,500 shares to 15,000 shares and the initial stock option grant from 20,000 shares to 30,000 shares;
3. approve an increase in shares reserved for issuance under the 1989 Stock Option Plan from 13,200,000 shares to 16,700,000 shares;
4. ratify the Audit Committee's selection of Ernst & Young LLP as independent auditors for our 2008 fiscal year; and
5. transact any other business that may be properly presented at the Annual Meeting.