The Board of Directors met seven times in 2007, five regularly scheduled meetings and two special meetings, and acted by unanimous written consent five times. During 2007, all Directors attended at least 85% of the meetings of the Board and the committees on which they served, except for Drs. DiMarchi and Reed. Drs. DiMarchi and Reed attended 80% of all the regularly scheduled meetings and 71% of all Board meetings, including the special meetings, due to short notice and scheduling conflicts. We encourage each member of the Board to attend the Annual Meeting of Stockholders. Last year, Dr. Berthelsen, Dr. Crooke, Mr. Klein, Ms. Parshall and Dr. Reed attended our 2007 Annual Meeting of Stockholders.

2006

The Board of Directors met six times in 2006, four regularly scheduled meetings and two special meetings, and acted by unanimous written consent four times. During 2006, all Directors, except Dr. Reed, attended at least 75% of the meetings of the Board and the committees on which they served. Dr. Reed attended 75% of all the regularly scheduled meetings and 50% of all of the special meetings, due to scheduling conflicts. We encourage each member of the Board to attend the Annual Meeting of Stockholders. Last year, Dr. Crooke, Mr. Klein, Ms. Parshall and Dr. Reed attended our 2006 Annual Meeting of Stockholders.

2005

The Board of Directors met five times in 2005, four regularly scheduled meetings and one special meeting, and acted by unanimous written consent six times. During 2005, all Directors attended at least 80% of the meetings of the Board and the committees on which they served, except Mr. Gabrieli who attended only 33% of the Audit Committee meetings due to personal schedule conflicts. We encourage each member of the Board to attend the Annual Meeting of Stockholders. None of our Board members, other than Dr. Crooke and Ms. Parshall, attended our 2005 Annual Meeting of Stockholders.